Volume 38, Issue 6 p. 758-760
Case Report (Series)

Elevated Triglycerides Levels in Two Infants With Hypoxic-ischemic Encephalopathy Undergoing Therapeutic Hypothermia and Receiving Parenteral Nutrition

Joseph Y. Ting MBBS, MRCPCH, MPH

Corresponding Author

Joseph Y. Ting MBBS, MRCPCH, MPH

Division of Neonatology, Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada

Joseph Y. Ting, MBBS, MRCPCH, MPH, Division of Neonatology, Department of Pediatrics, University of British Columbia, 4480 Oak Street, Vancouver, BC V6H 3V4, Canada. Email: [email protected]Search for more papers by this author
Deepak Manhas MD, FRCPC

Deepak Manhas MD, FRCPC

Division of Neonatology, Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada

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Sheila M. Innis MSc, PhD

Sheila M. Innis MSc, PhD

Division of Neonatology, Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada

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Susan Albersheim MD, FRCPC, PhD

Susan Albersheim MD, FRCPC, PhD

Division of Neonatology, Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada

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First published: 26 July 2013
Citations: 4

Abstract

Therapeutic hypothermia has been widely applied to improve the survival/neurodevelopmental outcomes among infants with moderate-to-severe hypoxic ischemic encephalopathy (HIE). Due to their critical condition and concerns over feeding tolerance, it is not uncommon to withhold enteral feeds and provide parenteral nutrition (PN) during hypothermia and early rewarming. Here we report 2 infants with HIE undergoing therapeutic hypothermia, and receiving PN, who exhibited early elevated triglyceride levels. Hypertriglyceridemia can be associated with neurologic complications, ranging from altered mental status, or irritability to seizures. Given the possible altered lipid metabolism under hypothermic conditions, we advocate close monitoring of lipid tolerance and conducting further prospective trials to elucidate lipid metabolism in these infants.